ABSTRACT
@#Burning mouth syndrome (BMS) is a chronic oral and facial pain disorder characterized by burning pain in the oral mucosa, with multiple pathogenic factors including psychosocial, neuropathological, endocrine, and immune factors. There is still a lack of effective treatment options that have been demonstrated to work. With the development of research on the pathogenesis and treatment of BMS, multidisciplinary comprehensive treatment has gradually been introduced and become a new trend of diagnosis and treatment. Before multidisciplinary treatment, it is necessary to go through a full and comprehensive diagnosis and analysis, select the best comprehensive treatment plan, take the diagnosis and treatment of stomatology as the basis and premise, and apply other multidisciplinary combined treatment, including the treatment of concurrent diseases, psychological interventions, correction of bad habits, etc. A combination of laser therapy and psychological intervention is a more effective treatment method among the current treatment methods, with high comfort and good acceptance by patients. If necessary, mecobalamin tablets, clonazepam α-lipoic acid and other drugs can be used to nourish nerves and provide symptomatic treatment. The comprehensive multidisciplinary treatment of BMS is expected to become a new trend and provide a new strategy for improving the therapeutic effect.
ABSTRACT
@#In recent years, spinal muscular atrophy (SMA) has made progress in multidisciplinary treatment and disease-modifying therapeutic drugs, so that the progress has significantly improved the survival and quality of life of the patients. However, no clinical practice guideline has developed for the management of SMA in adults and adolescents patients. Experts of multidisciplinary from a number of tertiary medical centers in China who specialize in the diagnosis and treatment of SMA have come to an agreement based on the evidence-based medicine. This guideline serves as instrumental reference for the standardized care of the Chinese SMA patients.
ABSTRACT
@#In recent years, spinal muscular atrophy (SMA) has made progress in multidisciplinary treatment and disease-modifying therapeutic drugs, so that the progress has significantly improved the survival and quality of life of the patients. However, no clinical practice guideline has developed for the management of SMA in adults and adolescents patients. Experts of multidisciplinary from a number of tertiary medical centers in China who specialize in the diagnosis and treatment of SMA have come to an agreement based on evidence-based medicine. This guideline serves as instrumental reference for the standardized care of the Chinese SMA patients.
ABSTRACT
In recent years, spinal muscular atrophy (SMA) has made progress in multidisciplinary treatment and disease-modifying therapeutic drugs, so that the progress has significantly improved the survival and quality of life of the patients. However, no clinical practice guideline has developed for the management of SMA in adults and adolescents patients. Experts of multidisciplinary from a number of tertiary medical centers in China who specialize in the diagnosis and treatment of SMA have come to an agreement based on the evidence-based medicine. This guideline serves as instrumental reference for the standardized care of the Chinese SMA patients.
ABSTRACT
@#Class I malocclusions with severe crowding and tooth size discrepancies may be successfully treated orthodontically with extraction therapy, and co-management with other specialists. Correction of the discrepancies will optimize occlusal result (overjet, overbite, midline shift, and smile esthetics). This is a case of a 19-year-old male with severe crowding in upper and lower teeth and peg lateral incisor. The patient had malocclusion Class I. This case was treated comprehensively and successfully using fixed orthodontic appliances with extraction of four premolars, and veneer composite for peg lateral incisor with the help of a conservative dentist at the end of orthodontic treatment.
ABSTRACT
OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.
Subject(s)
Humans , Disease Management , Heart Failure/therapy , Brazil , Cross-Sectional Studies , Surveys and QuestionnairesABSTRACT
Objective: multidisciplinary treatment has become increasingly common in dental offices and this treatment strategy is based on the achievement of a healthy, harmonious, and pleasant smile. In addition, the development of new ceramic systems and the possibility of making indirect restorations with a low thickness, such as laminates veneers, allowed combining highly satisfactory aesthetic properties, preserving the dental structure through minimally Invasive technique. Case report: this paper describes a multidisciplinary approach involving periodontics and restorative dentistry for the successful, functional, and aesthetic treatment in an adult patient. The digital smile design was performed as a guide to plan the clinical case considering factors such as tooth inclination and position, golden proportion, tooth size and shape. Discussion: based on these concepts, the present work reports, through a clinical case, the restoration of aesthetics and function with ceramic laminates veneers in lithium disilicate, in the case of anatomical correction and diastema closure. Conclusion: overall, the multidisciplinary treatment plan demonstrated to have greater advantages both for the aesthetics and function of the patient, as well as for the work team. During the 24-month follow-up, this case presented great functional and aesthetics results. (AU)
Introdução: o tratamento multidisciplinar tornou-se cada vez mais comum nos consultórios odontológicos, sendo uma estratégia baseada no tratamento da obtenção de um sorriso saudável, harmonioso e agradável. Além disso, o desenvolvimento de novos sistemas cerâmicos e a possibilidade de fazer restaurações indiretas com baixa espessura, como facetas laminadas, permitiram combinar propriedades estéticas altamente satisfatórias, preservando a estrutura dentária com o mínimo desgaste. Caso clínico: este artigo descreve uma abordagem multidisciplinar envolvendo Periodontia e Odontologia restauradora para um tratamento funcional e estético em um paciente adulto. O desenho digital do sorriso foi realizado como um guia para planejar o caso clínico, considerando fatores como inclinação e posição do dente, proporção áurea, tamanho e formato do dente. Discussão: com base nesses conceitos, o presente trabalho relata, através de um caso clínico, a restauração estética e funcional com laminados cerâmicos em dissilicato de lítio para correção anatômica e fechamento de diastemas. Conclusão: em geral, o plano de tratamento multidisciplinar demonstrou ter maiores vantagens tanto para a estética e função do paciente, quanto para a equipe de trabalho. Durante os 24 meses de acompanhamento, esse caso apresentou ótimos resultados funcionais e estéticos. (AU)
Subject(s)
Dental Veneers , Esthetics, DentalABSTRACT
Intrahepatic cholangiocellular carcinoma (ICC) has become the second common malignant tumors of the liver,with its incidence being next only to hepatocellular carcinoma (HCC).Due to the lack of targeted screening methods and specific clinical manifestations,most intrahepatic cholangiocarcinoma (ICC) is clearly diagnosed as advanced,which brings great difficulties to the treatment of ICC.At present,radical surgical resection is still the most effective method to ICC.However,for some patients who had a positive-margin (R1) resection or positive lymph node metastasis,multidisciplinary comprehensive treatment including transcatheter arterial chemoembolization (TACE),local ablation,systemic chemotherapy,targeted therapy and immunotherapy,etc.can effectively improve the prognosis of these patients.
ABSTRACT
The treatment of locally recurrent rectal cancer (LRRC) is multidisciplinary, including surgery, external beam radiotherapy, intraoperative radiotherapy, radioactive seed implantation, hyperthermia therapy, radiofrequency ablation, etc. Nevertheless, the predominant treatments are surgery and radiotherapy. Complete resection (R0 resection) is an independent prognostic factor. With the advent of intensity modulated radiation therapy (IMRT) and stereotactic body radiotherapy (SBRT), the efficacy of re-irradiation for patients who have previously received radiotherapy is confirmed, and the side effects are acceptable. Moreover, with the development of more treatment modalities, the survival rate and local control rate of patients are increasing, and the quality of life is improved. In conclusion, the treatment of LRRC is comprehensive and requires the participation of multidisciplinary physicians. However, proper and effective treatment needs more research evidence. This review summarized the latest progress in the multidisciplinary treatment of LRRC and the unresolved problems.
ABSTRACT
OBJECTIVE: To explore pharmacist's practice patterns of medication therapy management(MTM) with physician in multidisciplinary treatment(MDT). METHODSE: Implement a medication therapy management of one deep venous thrombosis(DVT)pregnant patient in MDT, including collecting patient's information, assessing disease risks and treatment problems, designing medication plans and providing medication guidance of folic acid, etc. RESULTS: During pregnancy, there was no thrombus complication, the fetus was healthy and there was no thrombus recurrence. CONCLUSION: In multidisciplinary treatment, pharmacists can solve drug-treatment problems for patients with the rationality, safety and effectiveness.
ABSTRACT
@#Objective To give an annual data report of surgical treatment of esophageal cancer in Shanghai Chest Hospital to provide reference for treatment and research on esophageal cancer. Methods The clinical data of 414 patients with esophageal cancer who underwent endoscopy (9 patients) and esophagectomy (405 patients) in Shanghai Chest Hospital in 2015 were reviewed, including 334 males and 80 females. Their tumor biological characteristics and short-term and long-term treatment results were analyzed. Results Patients in this group were predominantly aged 60 to 69 years (46.9%), and the tumor was mainly located in the middle thorax (50.7%). About 79.9% of the patients received trans-right thoracic esophagectomy, 44.4% received minimally invasive surgery; 388 (93.7%) patients accepted upfront esophagectomy without induction therapy, and 179 (43.2%) patients received postoperative adjuvant therapy. The R0 resection rate was 90.6%, and the 30- and 90-day mortality rates were 1.4% and 2.4%, respectively. The 4-year overall survival rate of the R0 resection patients was 65.7%. Conclusion Satisfactory long-term survival results can be obtained for thoracic esophageal cancer if R0 resection can be achieved by trans-right thoracic esophagectomy and extended lymphadenectomy combined with appropriate postoperative adjuvant treatment.
ABSTRACT
Intrahepatic cholangiocellular carcinoma (ICC) has become the second common malignant tumors of the liver, with its incidence being next only to hepatocellular carcinoma (HCC). Due to the lack of targeted screening methods and specific clinical manifestations, most intrahepatic cholangiocarcinoma(ICC)is clearly diagnosed as advanced, which brings great difficulties to the treatment of ICC. At present, radical surgical resection is still the most effective method to ICC. However, for some patients who had a positive-margin (R1) resection or positive lymph node metastasis, multidisciplinary comprehensive treatment including transcatheter arterial chemoembolization (TACE), local ablation, systemic chemotherapy, targeted therapy and immunotherapy, etc. can effectively improve the prognosis of these patients.
ABSTRACT
The current situation of pancreatic cancer is that the etiology is not clear and prevention is difficult. The sensitivity and specificity of the auxiliary detection method are low, and early diagnosis is a worldwide problem. The efficacy of existing treatment method is not satisfied and is difficult to break through in a short time. The 5-year overall survival rate is only 7.2%. In face of the current situation of pancreatic cancer, the key solution is to strengthen basic research, explore its etiology and pathogenesis, prevent carcinogenesis and development. Developments of the efficacy of peripheral blood and urine detection technology, imaging diagnosis technology are the critical manners to improve the early diagnosis rate. However, the research on basic and early diagnosis techniques takes a long time and costs a lot, which makes it difficult to achieve result in a short time. Therefore, the problem to be solved urgently is to develop a personalized treatment plan through standardized multi-disciplinary treatment (MDT), optimized combination of existing diagnosis and treatment methods, which may achieve the purpose of improving efficacy. This expert consensus is developed from the first edition, which is based on the diagnosis and treatment status of pancreatic cancer and the dilemma that is difficult to break through in a short time, with reference to the successful diagnosis and treatment experience at home and abroad, combined with the national condition of our country, repeated deliberation, discussion and revision by many domestic well-known experts. This consensus discusses the meaning and purpose, the main tasks, the necessary objective conditions for carrying out, workflows, precautions, relevant clinical and basic research of MDT, explorations of multi-center MDT mode and internet MDT (eMDT) mode in detail. Through the formulation and publication of this consensus, we hope that it can promote the development of standardized pancreatic cancer MDT and improve the therapeutic efficacy of pancreatic cancer in China, summarize successful experience and promote international exchanges, strengthen personnel training and echelon construction, formulate relevant policy and promote the development of MDT in the whole country. This is an expert consensus on the MDT model developed in China, which is not only applied to pancreatic cancer, but also can be used as a reference for other tumors.
ABSTRACT
@#Class I malocclusions with severe crowding and tooth size discrepancies may be successfully treated orthodontically with extraction therapy, and co-management with other specialists. Correction of the discrepancies will optimize occlusal result (overjet, overbite, midline shift, and smile esthetics). This is a case of a 19-year-old male with severe crowding in upper and lower teeth and peg lateral incisor. The patient had malocclusion Class I. This case was treated comprehensively and successfully using fixed orthodontic appliances with extraction of four premolars, and veneer composite for peg lateral incisor with the help of a conservative dentist at the end of orthodontic treatment.
Subject(s)
Malocclusion, Angle Class IABSTRACT
Objective@#To summarize the treatment options for congenital maxillary lateral incisor agenesis (MLIA).@*Methods @#Review the literature, summarize the current treatment options and advantages and disadvantages of various methods of MLIA, and analyze cases. @*Results @#When a patient′s occlusion and other conditions are suitable for space closure and canine substitution, closure of the gap is the recommended method, as it has good aesthetic results and leads to good periodontal health. However, when closure cannot be performed, a dental implant has a strong advantage compared with other restoration methods. When planning implants for MLIA patients, doctors should carefully select the correct surgery time and take care with the implant position to obtain good results.@* Conclusion@#In the choice of a treatment plan for MLIA, we need to use the concept of multidisciplinary combined treatment to obtain a more satisfactory treatment effect with regard to aesthetics and function.
ABSTRACT
Some of the patients with hepatocellular carcinoma could be performed hepatectomy and get optimal postoperative outcomes with tumor-free long-term survival which encourage surgeon to carry on the surgery with tremendous enthusiam.Unfortunately the others are not the case even though surgeons have done their best routinely and standardly and the tumor recurs in the liver in short time after surgery. For the sake of the patient treatment,the confidence should not be lost,there are a lot of things to be done which include re-resection, radio freuquency ablation,transcatheter arterial chemoembolization,liver transplantation respectively and individualizedly in order to receive better prognosis and longer-term survival.
ABSTRACT
Surgical treatment of thyroid cancer with surrounding structures involved remains a challenge for physicians.Trachea and larynx are common affected organs,and complete resection can bring the greatest survival benefit.However,postoperative quality of life may be greatly affected.It is necessary to improve the quality of life of patients by stage Ⅰ or Ⅱ reconstruction. The case of papillary thyroid carcinoma invading the internal jugular vein or with internal jugular vein tumor thrombus can still be safely and completely removed.Some cases with carotid artery invasion could benefit from radical resection,in which case vascular reconstruction should be done simultaneously.Multidisciplinary treatment should be emphasized for the locally advanced cases. Postoperative radioactive iodine therapy,external beam radiotherapy,endocrine therapy should be considered to reduce local recurrence. For inoperable patients,participating a clinical trial or trying targeted therapy could be good choices. Patients with poor general condition may be given palliative care to alleviate the symptoms.
ABSTRACT
Objetivo: Mostrar una alternativa de tratamiento para las fracturas coronorradiculares complicadas, que restablece la función y la estética de las piezas traumatizadas. Caso clínico: Una paciente de 16 años se presentó en la guardia del Centro Odontológico OSEP tras haber sufrido un accidente vial que le produjo un traumatismo dentoalveolar. El diagnóstico fue fractura coronaria sin exposición pulpar de la pieza dentaria 12 y fractura coronorradicular complicada de la pieza 11. El tratamiento incluyó restauración con resina compuesta de la pieza 12 y endodoncia, extrusión ortodóntica, alargamiento coronario y rehabilitación con perno de fibra de cuarzo y corona de resina compuesta de la pieza 11. Conclusiones: El tratamiento de las fracturas coronorradiculares representa un desafío para el odontólogo. Los resultados del tratamiento, en este paciente, fueron excelentes, ya que lograron devolver estética y función (AU)
Aim: To show an alternative treatment for complicated crown-root fractures, which restores function and aesthetics of the traumatized teeth. Case report: This paper reports the case of a 16-yearold girl who attends the OSEP Dental Center, stating that she had suffered a traffic accident resulting in a dentoalveolar trauma. The diagnosis was a coronary fracture without pulp exposure of tooth 12, and complicated crown-root fracture of tooth 11. Treatment included composite resin restoration of tooth 12 and endodontic, orthodontic extrusion, crown lengthening and rehabilitation with quartz fiber post and composite resin crown of tooth 11. Conclusions: The treatment of crown-root fractures poses a challenge for the dentist. The results of the treatment in this patient were excellent, and aesthetics and function were restored (AU)
Subject(s)
Humans , Female , Adolescent , Crown Lengthening , Orthodontic Appliances , Patient Care Team , Tooth Fractures , Tooth Injuries , Tooth Root , Argentina , Composite Resins , Post and Core Technique , Quartz , Tooth Crown , Tooth SocketABSTRACT
Las fracturas abiertas de pelvis son un desafío clínico y quirúrgico como consecuencia de la gravedad de las lesiones óseas, de órganos internos, de partes blandas, hemorragia y cobertura cutánea. Su frecuencia es baja con una incidencia del 2-4%. La mortalidad llega a ser del 15-25% en fracturas cerradas y alcanza hasta el 50% en fracturas abiertas. La primera causa de mortalidad suele ser por shock hemorrágico. Presentamos un caso clínico tratado en el Servicio de Cirugía Ortopédica y Traumatología (COT) del Complejo Hospitalario Universitario de Santiago de Compostela (CHUS). Tras el análisis de los datos obtenidos de la revisión de este caso y la bibliografía correspondiente, podríamos afirmar que, ante una fractura de pelvis abierta, en primer lugar hay que asegurar la supervivencia en el momento inicial y proceder al control inicial de la hemorragia y la estabilidad pélvica. Posteriormente, debe llevarse a cabo el tratamiento quirúrgico inicial urgente multidisciplinario. Por último, debe pasarse a un tratamiento definitivo mediante reducción abierta y fijación interna. Hay que considerar también, por su importancia, el gran número de secuelas que produce este tipo de lesiones, algo que debemos prever y minimizar en la medida de lo posible. Nivel de evidencia clínica. Nivel IV.
Open pelvic fractures are a clinical and surgical challenge because of the severity of bone lesions, internal organs, soft tissue, skin coverage and hemorrhage. Its frequency is low with an incidence of 2-4%. The mortality is as high as 15-25% in closed fractures and to 50% in open fractures. The leading cause of death is usually by hypovolemic shock. We report a case treated in the Department of Orthopedic Surgery and Trauma (COT) of the University Hospital of Santiago de Compostela (CHUS). After analyzing the data obtained from the review of this case and the relevant literature, we could say that, in an open fractured pelvis first thing to do is to ensure survival at the initial time and the initial control of bleeding and pelvic stability, subsequently an urgent multidisciplinary initial surgical treatment should be performed. And finally, a definitive treatment by open reduction and internal fixation has to be accomplished. Sequels that this type of injury produce have also been considered since the initial patient evaluation in order to anticipate and minimize them as much as possible. Evidence level. IV.
Subject(s)
Humans , Fractures, Bone , Pelvis , Therapeutics , ReinjuriesABSTRACT
Primary hepatocellular carcinoma (PHC) is a common malignant tumor in our country,which seriously threatens people's health.As China gradually enters the aging society,the elderly over 60 years old take up for 13％ of the total population.The incidence of PHC in the elderly is increasing at the same time.At present,the incidence of hepatocarcinoma in China is the third highest among malignant tumors,and 47.5％ of the patietns are elderly patients.As the elderly patients are often accompanied by cardiovascular and cerebrovascular diseases,diabetes and other complications,making the treatment of PHC in the elderly become much more difficult.Therefore,adopting a comprehensive treatment model of multiple therapies to improve the quality of life of patients and prolong the survival time of patients,has become the key issue.This article reviews the current progress in the clinical treatment of PHC in the elderly.